What are Polynucleotides

Polynucleotides are bio-stimulators derived from fragments of salmon DNA.

They are injected under the skin with an ultra-fine needle and work at a cellular level by activating specific receptors on fibroblast cells in the tissues.

Stimulation of the fibroblasts prompts a healing response in the tissues, resulting in visible skin regeneration. Benefits include reduced inflammation and scarring, rapid cell regeneration, and increased collagen and elastin production. Our polynucleotides treatments are designed to address a wide range of aesthetic concerns, from reducing fine lines and wrinkles to improving skin texture and tone.

Nucleofill is a biolstimulant gel based on natural polynucleotides (PDRN). Innovation in skin rejuvenation and anti-aging prevention. The effectiveness of this treatment is proven scientifically: it moisturizes, thickens, and firms the skin, restores its natural glow. The skin will gradually look younger as the product is working deep inside the skin producing collagen and elastin. We recommend a course of 3-4 treatments, each treatment 4 weeks apart. Medium for clients under 40, and Strong for more mature ladies, those with aged skin, or men.

Polynucleotide treatment under the eyes

Reduces Dark Circles: Improves microcirculation to diminish dark circles.
Minimises Puffiness: Enhances lymphatic drainage, reducing under-eye bags.
Smoothes Fine Lines: Boosts collagen and elastin production for firmer skin.
Anti-Inflammatory: Reduces inflammation and soothes sensitive skin.
Antioxidant Protection: Shields skin from free radical damage, slowing the ageing process.

Lumi eyes It is a mesotherapy treatment, that uses polynucleotides with strong regenerating properties to repair damaged skin under the eyes. This injectable treatment hydrates, reduces fatigue, and fights skin discoloration. Polynucleotide PDRN stimulates collagen synthesis and elastin production, and provides antioxidant effects. Lumi Eyes targets dark circles, moisturizes, smooths wrinkles, and lifts the skin. It improves firmness and skin quality naturally. Enjoy a youthful and refreshed look with this quick-absorbing treatment.

Sessions: Typically 2–4 sessions spaced 4 weeks apart, with maintenance treatments recommended annually.

Duration: Results are visible within 1 week, with full effects developing over 1–2 months.
Outcomes last 6–8 months, depending on skin condition and aftercare.

Close-up comparison of an eye showing wrinkles "Before" and smooth skin "After."
Advertisement for PromoItalia Nucleofill Strong, highlighting its antioxidant, lifting, and hydrating properties, featuring a woman with a facial diagram.